journals.iop.org home page electronic journals * User guide   * Site map   | Quick Search:Help  
Journal of Physics: Conference Series
Athens/Institutional login
IOP login: Password:   
Create account | Alerts | Contact us
Journals Home | Journals List | EJs Extra | This Journal | Search | Authors | Referees | Librarians | User Options | Help |

Degradation of platinum based anticancer drugs by methionine: An EXAFS study

K Provost et al 2009 J. Phys.: Conf. Ser. 190 012206 (4pp)   doi: 10.1088/1742-6596/190/1/012206  Help

   PDF (623 KB) | References

K Provost1, D Bouvet-Muller1, S Crauste-Manciet2, L Olivi3, G Vlaic3 and A Michalowicz1
1 ICMPE, UMR 7182 CNRS-Université Paris 12, 94320 Thiais, France
2 Laboratoire de Pharmacie Galénique, Université Paris Descartes, 75006 Paris, France
3 EXAFS Beamline, ELETTRA, Sincrotone Trieste, 34012 Basovizza, Trieste, Italy
E-mail: provost@univ-paris12.fr

Abstract. We characterized the structures in solution of carboplatin and oxaliplatin degradation products in presence of a large excess of methionine (Met). The reaction of carboplatin leads to the formation of cis-Pt(Met)2 while, in the case of oxaliplatin, methionine displaces only the oxalate ligand to form Pt(diaminocyclohexane)(Met).

Bookmark and Share Post to CiteUlike | Post to Connotea | Post to Bibsonomy

 


Find related articles





Article options

Authors & Referees

 
Content finder
  Full Search
  Help


  
Setup information is available for Adobe Acrobat.
EndNote, ProCite ® and Reference Manager ® are registered trademarks of ISI Researchsoft.
Copyright © Institute of Physics and IOP Publishing Limited 2009.
Use of this service is subject to compliance with the Terms and Conditions of use. In particular, reselling and systematic downloading of files is prohibited.
Help: Cookies | Data Protection. Privacy policy Disclaimer