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Finding mesoscopic communities in sparse networks

I Ispolatov et al J. Stat. Mech. (2006) P09014   doi: 10.1088/1742-5468/2006/09/P09014  Help

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I Ispolatov1, I Mazo and A Yuryev
Ariadne Genomics Inc., 9700 Great Seneca Highway, Suite 113, Rockville, MD 20850, USA
1 Permanent address: Departamento de Fisica, Universidad de Santiago de Chile, Casilla 302, Correo 2, Santiago, Chile
E-mail: iispolat@lauca.usach.cl, mazo@ariadnegenomics.com and ayuryev@ariadnegenomics.com

Abstract. We suggest a fast method for finding possibly overlapping network communities of a desired size and link density. Our method is a natural generalization of the finite-T superparamagnetic Potts clustering introduced by Blatt et al (1996 Phys. Rev. Lett. 76 3251) and the annealing of the Potts model with a global antiferromagnetic term recently suggested by Reichardt and Bornholdt (2004 Phys. Rev. Lett. 93 218701). Like in both cited works, the proposed generalization is based on ordering of the ferromagnetic Potts model; the novelty of the proposed approach lies in the adjustable dependence of the antiferromagnetic term on the population of each Potts state, which interpolates between the two previously considered cases. This adjustability allows one to empirically tune the algorithm to detect the maximum number of communities of the given size and link density. We illustrate the method by detecting protein complexes in high-throughput protein binding networks.

Key words: molecular networks (experiment); random graphs, networks; genomic and protemic networks

E-print number: q-bio.MN/0512038
Cited: by
Refers: to

Received 29 June 2006, accepted for publication 7 September 2006
Published 26 September 2006

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