Positive pressure infusion of fluorescent nanoparticles
as a probe  of the structure of brain phantom gelatins

doi:10.1088/0957-4484/13/4/308

Positive pressure infusion of fluorescent nanoparticles as a probe of the structure of brain phantom gelatins

G T Gillies et al 2002 Nanotechnology 13 484-486 doi: 10.1088/0957-4484/13/4/308

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G T Gillies^1,2, S W Allison³ and B M Tissue⁴
¹ Department of Mechanical and Aerospace Engineering, University of Virginia, PO Box 400746, Charlottesville, VA 22904-4746, USA
² Division of Neurosurgery, Virginia Commonwealth University, PO Box 631, Richmond, VA 23298-0631, USA
³ Oak Ridge National Laboratory, NTRC, 2360 Cherahala Blvd, MS6472, Knoxville, TN 37932-6472, USA
⁴ Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0212, USA
E-mail: gtg@virginia.edu, allisonsw@ornl.gov and tissue@vt.edu

Abstract. Positive pressure infusion of Y₂O₃:Eu³⁺ particles 8-12 nm in size was carried out in 75 cm³ samples of 0.6% agarose gels that have internal mass transport properties similar to those of in vivo mammalian brain tissue. The purpose of the study was to investigate the nature of the porous-like structure of the gels at distance scales of the order of approx 10 nm. Fluorescence of the particles under UV excitation was used to observe their time-dependent distribution pattern, with the result that the convection-enhanced flow provided by the infusion process caused the particles to permeate the gel's interstitial structure, thus revealing a porosity scale size commensurate with that of the particle size.

Print publication: Issue 4 (August 2002)
Received 21 February 2002
Published 21 June 2002

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Positive pressure infusion of fluorescent nanoparticles as a probe of the structure of brain phantom gelatins

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