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TOPICAL REVIEW

Photoacoustic tomography and sensing in biomedicine

Changhui Li et al 2009 Phys. Med. Biol. 54 R59-R97   doi: 10.1088/0031-9155/54/19/R01  Help

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Changhui Li and Lihong V Wang
Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
E-mail: lhwang@biomed.wustl.edu

Abstract. Photoacoustics has been broadly studied in biomedicine, for both human and small animal tissues. Photoacoustics uniquely combines the absorption contrast of light or radio frequency waves with ultrasound resolution. Moreover, it is non-ionizing and non-invasive, and is the fastest growing new biomedical method, with clinical applications on the way. This review provides a brief recap of recent developments in photoacoustics in biomedicine, from basic principles to applications. The emphasized areas include the new imaging modalities, hybrid detection methods, photoacoustic contrast agents and the photoacoustic Doppler effect, as well as translational research topics.

Print publication: Issue 19 (7 October 2009)
Received 3 February 2009, in final form 4 August 2009
Published 1 September 2009

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