Development of a remanence measurement-based SQUID system

doi:10.1088/0031-9155/54/10/N01

NOTE

Development of a remanence measurement-based SQUID system with in-depth resolution for nanoparticle imaging

Song Ge et al 2009 Phys. Med. Biol. 54 N177-N188 doi: 10.1088/0031-9155/54/10/N01

PDF (282 KB) | References

Song Ge^1,2, Xiangyang Shi^2,4, James R Baker Jr², Mark M Banaszak Holl^2,3 and Bradford G Orr^1,2,4
¹ Department of Physics, University of Michigan, Ann Arbor, MI 48109, USA
² Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA
³ Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
⁴ Present address: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201602, People's Republic of China
Author to whom any correspondence should be addressed
E-mail: orr@umich.edu

Abstract. We present a remanence measurement method using a superconducting quantum interference device (SQUID) to detect trace amounts of magnetic nanoparticles (MNPs). Based on this method, a one-dimensional scanning system was established for imaging. The system was calibrated with 25 nm diameter Fe₂O₃ nanoparticles (NPs), and the sensitivity of the NPs was found to be 10 ng at a distance of 1.7 cm and the spatial resolution was ~1 cm. A theoretical model of this system was developed and applied to the deconvolution of scanned images of phantoms with two NP injection spots. Using the developed SQUID system, we were able to determine not only the amount and horizontal positions of the injections, but also their depths in the phantoms.

Print publication: Issue 10 (21 May 2009)
Received 9 February 2009, in final form 20 March 2009
Published 27 April 2009

Post to CiteUlike |

Post to Connotea |

Post to Bibsonomy

Development of a remanence measurement-based SQUID system with in-depth resolution for nanoparticle imaging

Find related articles

Article options

Authors & Referees