Vascular term in the reference region model

doi:10.1088/0031-9155/53/10/012

Incorporating a vascular term into a reference region model for the analysis of DCE-MRI data: a simulation study

A Z Faranesh et al 2008 Phys. Med. Biol. 53 2617-2631 doi: 10.1088/0031-9155/53/10/012

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A Z Faranesh¹ and T E Yankeelov^2,3
¹ Department of Radiology, Stanford University, Stanford, CA 94305-5488, USA
² Institute of Imaging Science, Departments of Radiology and Radiological Sciences, Biomedical Engineering, Physics and Astronomy, Vanderbilt University, Nashville, TN, USA
³ Current address: National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, MSC 1538, Bldng 10, Rm 2C713, Bethesda, MD 20892-1538, USA
E-mail: faranesh@nih.gov

Abstract. A vascular term was incorporated into a reference region (RR) model analysis of DCE-MRI data, and its effect on the accuracy of the model in estimating tissue kinetic parameters in a tissue of interest (TOI) was systematically investigated through computer simulations. Errors in the TOI volume transfer constant (K^trans,TOI) and TOI extravascular extracellular volume (v_e,TOI) that result when the fractional plasma volume (v_p) was included in (1) neither region, (2) TOI only (3) both regions were investigated. For nominal values of tumor kinetic parameters (v_e,TOI = 0.40 and K^trans,TOI = 0.25 min⁻¹), if the vascular term was included in neither region or the TOI only, K^trans,TOI error was within 20% for 0.03 < v_p,TOI < 0.10, and v_e,TOI error was within 20% for the range of v_p,TOI studied (0.01–0.10). The effects of temporal resolution were shown to be complex, and in some cases errors increased with increasing temporal resolution.

Print publication: Issue 10 (21 May 2008)
Received 16 October 2007, in final form 1 April 2008
Published 25 April 2008

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Incorporating a vascular term into a reference region model for the analysis of DCE-MRI data: a simulation study

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