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Evaluation of x-ray diffraction enhanced imaging in the diagnosis of breast cancer

Chenglin Liu et al 2007 Phys. Med. Biol. 52 419-427   doi: 10.1088/0031-9155/52/2/008  Help

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Chenglin Liu1,2, Xiaohui Yan1, Xinyi Zhang1,3, Wentao Yang4, Weijun Peng4, Daren Shi4, Peiping Zhu5, Wanxia Huang5 and Qingxi Yuan5
1 Synchrotron Radiation Research Center, Physics Department, Surface Physics Laboratory (National Key Laboratory) of Fudan University, Shanghai 200433, People's Republic of China
2 Physics Department of Yancheng Teachers' College, Yancheng 224002, People's Republic of China
3 Shanghai Research Center of Acupuncture and Meridian, Pudong, Shanghai 201203, People's Republic of China
4 Cancer Hospital, Medical Center of Fudan University, Shanghai 200032, People's Republic of China
5 Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100039, People's Republic of China
E-mail: xy-zhang@fudan.edu.cn

Abstract. The significance of the x-ray diffraction enhanced imaging (DEI) technique in the diagnosis of breast cancer and its feasibility in clinical medical imaging are evaluated. Different massive specimens including normal breast tissues, benign breast tumour tissues and malignant breast tumour tissues are imaged with the DEI method. The images are recorded respectively by CCD or x-ray film at different positions of the rocking curve and processed with a pixel-by-pixel algorithm. The characteristics of the DEI images about the normal and diseased tissues are compared. The rocking curves of a double-crystal diffractometer with various tissues are also studied. The differences in DEI images and their rocking curves are evaluated for early diagnosis of breast cancers.

Print publication: Issue 2 (21 January 2007)
Received 8 March 2006, in final form 20 August 2006
Published 29 December 2006

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