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Optimization of MAGIC gel formulation for three-dimensional radiation therapy dosimetry

J J Luci et al 2007 Phys. Med. Biol. 52 N241-N248   doi: 10.1088/0031-9155/52/10/N03  Help

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J J Luci1,2, H M Whitney1,3 and J C Gore1,2,3
1 Vanderbilt University Institute of Imaging Science, Nashville, TN 37232-2675, USA
2 Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232-2675, USA
3 Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37232-2675, USA
E-mail: heather.whitney@vanderbilt.edu

Abstract. Polymer gel dosimetry aims to provide three-dimensional images of radiation therapy dose distributions in irradiated aqueous gels. The first gels required manufacture in an oxygen-free environment, but later the MAGIC formulation was introduced, which could be made in normal atmospheric conditions. Here we report our studies of the effects of variations in the composition of the MAGIC gel performed in order to optimize its performance over the useful dose range of 0 to 20 Gy. A new formulation (termed 'MAGIC-2') is comprised of 87% water, 4% methacrylic acid, 9% gelatin, 17.38 × 10−6 M Cu2+ and a molar ratio of ascorbic acid to [Cu2+] of 1000:1. MAGIC-2 has a dose–response slope-to-intercept ratio that is 78% greater than the original formulation and other more favorable properties.

Print publication: Issue 10 (21 May 2007)
Received 14 September 2006, in final form 28 March 2007
Published 24 April 2007

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