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Multi-nuclear MRS and 19F MRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: phantom studies at high magnetic fields

Paola Porcari et al 2006 Phys. Med. Biol. 51 3141-3154   doi: 10.1088/0031-9155/51/12/010  Help

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Paola Porcari1,2,3, Silvia Capuani2,3, Renzo Campanella4, Angela La Bella5, Luisa Maria Migneco5 and Bruno Maraviglia1,3,6
1 Physics Department, University 'La Sapienza', Rome, Italy
2 SOFT-INFM CNR, Physics Department, University 'La Sapienza', Rome, Italy
3 Enrico Fermi Center, Rome, Italy
4 Physics Department, University of Perugia, Italy
5 Chemistry Department, University 'La Sapienza', Rome, Italy
6 IRCCS Santa Lucia Foundation, Rome, Italy
E-mail: bruno.maraviglia@roma1.infn.it and silvia.capuani@roma1.infn.it

Abstract. Reaction yield optimization for the synthesis and the complexation of a boron neutron capture therapy agent 19F-labelled, 10B-enriched p-boronophenylalanine-fructose (19F-BPA-fr) complex was obtained. 1H, 19F, 13C and 10B magnetic resonance spectroscopy (MRS) of the 19F-BPA-fr complex in aqueous and rat blood solution phantoms and its spatial distribution mapping using 19F magnetic resonance imaging (MRI) results are reported. 7 T and 9.4 T magnetic fields were used to perform MRI and MRS respectively. Our in vitro results suggest that in vivo studies on 19F-BPA through 19F NMR will be feasible.

Print publication: Issue 12 (21 June 2006)
Received 13 March 2006
Published 6 June 2006

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